rsbT

rsbT
168

PP2C activator, protein serine kinase, phosphorylates RsbS and RsbR, part of the stressosome, also required for a stressosome-independent stress response via SigB

Locus
BSU_04690
Molecular weight
14.21 kDa
Isoelectric point
6.59
Protein length
133 aaSequenceBlast
Gene length
402 bpSequenceBlast
Function
control of SigB activity
Product
PP2C activator, protein serine kinase
Essential
no
Synonyms
rsbT, ycxT
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2172 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
520,606  521,007
The protein
Catalyzed reaction/ biological activity
phosphorylation of RsbR, RsbRB, RsbRC, and RsbRD PubMed
activation of RsbU phosphatase activity PubMed
ATP + L-seryl-[protein] --> ADP + H+ + O-phospho-L-seryl-[protein] (according to UniProt)
ATP + L-threonyl-[protein] --> ADP + H+ + O-phospho-L-threonyl-[protein] (according to UniProt)
Structure
1TIL (PDB) (the SpoIIAB-SpoIIAA complex of Geobacillus stearothermophilus, 28% identity) PubMed
P42411 (AlphaFold)
Effectors of protein activity
phosphorylated RsbR activates the kinase activity of RsbT PubMed
activity is stimulated by light in a YtvA-dependent manner PubMed
Expression and Regulation
Operons
Genes
rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sigB-rsbX
Description
PubMed
Regulation
''rsbV:'' induced by stress (SigB) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigB: sigma factor, PubMed, in sigB regulon
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rsbR→rsbX

2025-03-31 08:58:11

ghost

226

5f220975cc2493224a8aa0770ee2187c815a2127

3EFC8DC1AC54632D4F2AC30497749AB5CCA3A39F

Biological materials
Mutant
BKE04690 (rsbT::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TACACAGGATTGGTCGTTCA,  downstream forward: _UP4_TGGCTTCGGTAGGAGGTAAG
BKK04690 (rsbT::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TACACAGGATTGGTCGTTCA,  downstream forward: _UP4_TGGCTTCGGTAGGAGGTAAG
Labs working on this gene/protein
Bill Haldenwang, San Antonio, USA
Chet Price, Davis, USA homepage
Rick Lewis, Newcastle, UK homepage
References
Reviews
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Original Publications
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ADC52A22950736A0435AEEEC43F7407878786A81

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Time of last update: 2025-04-02 11:19:49

Author of last update: Jstuelk