Difference between revisions of "FtsH"

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(Expression and regulation)
(Extended information on the protein)
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
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* '''[[SubtInteract|Interactions]]:'''  
  
* '''Localization:''' cell membrane (according to Swiss-Prot),  membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]  
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* '''[[Localization]]:''' cell membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 20:17, 11 August 2011

  • Description: ATP-dependent metalloprotease

Gene name ftsH
Synonyms
Essential no
Product ATP-dependent metalloprotease
Function cell division, sporulation initiation
Metabolic function and regulation of this protein in SubtiPathways:
Phosphorelay, Stress
MW, pI 70 kDa, 5.841
Gene length, protein length 1911 bp, 637 aa
Immediate neighbours hprT, coaX
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FtsH context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

cell division, cell envelope stress proteins (controlled by SigM, W, X, Y), heat shock proteins, membrane proteins

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU00690

Phenotypes of a mutant

strongly reduced sporulation frequency

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: degrades Spo0E, resulting in reduced sporulation frequency in a ftsH mutant
  • Protein family:
  • Paralogous protein(s): YjoB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1LV7 (from E. coli, 64% identity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by heat shock (class III)
  • Regulatory mechanism:
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References