LiaH

• Description: resistance against oxidative stress and cell wall antibiotics (such as daptamycin)
  
  

Gene name	liaH
Synonyms	yvqH
Essential	no
Product	unknown
Function	resistance against oxidative stress and cell wall antibiotics
MW, pI	25 kDa, 6.172
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	liaG, liaI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics

This gene is a member of the following regulons

AbrB regulon, LiaR regulon

The gene

Basic information

• Locus tag: BSU33120

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: pspA/IM30 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: forms large oligomeric rings with a nine-fold rotational symmetry PubMed

• Localization: variable (spotty) protein PubMed

Database entries

• Structure:

• UniProt: O32201

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaI-liaH PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by bacitracin (LiaR) PubMed
  • repressed during logarithmic growth (AbrB) PubMed, probably indirect regulation by AbrB PubMed

• Regulatory mechanism:
  • LiaR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: