Difference between revisions of "DisA"
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=== Additional information=== | === Additional information=== | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' synthesizes the small molecule cyclic diadenosine monophosphate (c-di-AMP) {{PubMed|21566650}} |
* '''Protein family:''' disA family (according to Swiss-Prot) | * '''Protein family:''' disA family (according to Swiss-Prot) | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[RacA]] | + | * '''Interactions:''' [[RacA]]-[[DisA]] |
* '''Localization:''' see a [http://download.cell.com/mmcs/journals/0092-8674/PIIS0092867406005034.mmc12.avi video] showing the movement of DisA in the cell (in real time) [http://www.ncbi.nlm.nih.gov/pubmed/16713562 PubMed] | * '''Localization:''' see a [http://download.cell.com/mmcs/journals/0092-8674/PIIS0092867406005034.mmc12.avi video] showing the movement of DisA in the cell (in real time) [http://www.ncbi.nlm.nih.gov/pubmed/16713562 PubMed] | ||
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=References= | =References= | ||
| − | <pubmed>8793870,9987115,16713562,17434969,18714086,16713555,18439896,,11544224 17434969 18714086 18439896 16713562 16713555 12493822 </pubmed> | + | <pubmed>8793870,9987115,16713562,17434969,18714086,16713555,18439896,,11544224 17434969 18714086 18439896 16713562 16713555 12493822 21566650</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:42, 14 May 2011
- Description: DNA integrity scanning protein, delays sporulation in the case of chromosome damage, has diadenylate cyclase activity
| Gene name | disA |
| Synonyms | yacK |
| Essential | no |
| Product | DNA integrity scanning protein, has diadenylate cyclase activity |
| Function | control of sporulation initiation |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 40 kDa, 5.569 |
| Gene length, protein length | 1080 bp, 360 aa |
| Immediate neighbours | radA, yacL |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
cell division, metabolism of signalling nucleotides, sporulation/ other, general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, W, X, Y), heat shock proteins
This gene is a member of the following regulons
CtsR regulon, SigB regulon, SigM regulon
The gene
Basic information
- Locus tag: BSU00880
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: synthesizes the small molecule cyclic diadenosine monophosphate (c-di-AMP) PubMed
- Protein family: disA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 3C23
- UniProt: P37573
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
