Spo0E

• Description: Spo0A-P phosphatase, control of the phosphorelay
  
  

Gene name	spo0E
Synonyms
Essential	no
Product	Spo0A-P phosphatase
Function	initiation of sporulation
Function and regulation of this protein in SubtiPathways: Phosphorelay
MW, pI	9 kDa, 6.483
Gene length, protein length	255 bp, 85 aa
Immediate neighbours	ykvA, eag
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU13640

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: spo0E family (according to Swiss-Prot)

• Paralogous protein(s): YnzD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: Spo0F-Spo0E, Spo0A-Spo0E

• Localization:

Database entries

• Structure:

• UniProt: P05043

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spo0E PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information: Spo0E is degraded by FtsH

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Tony Wilkinson, York University, U.K. homepage

References

Reviews

Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980] [WorldCat.org] [DOI] (I p)