swrB

swrB
168

control of SigD activity, required for full SigD activity, activates the flagellar type III secretion export apparatus by the membrane protein FliP

Locus
BSU_16480
Molecular weight
18.98 kDa
Isoelectric point
4.42
Protein length
167 aaSequenceBlast
Gene length
504 bpSequenceBlast
Function
control of SigD activity
Product
unknown
Essential
no
Synonyms
swrB, ylxL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
1,717,286  1,717,789
Phenotypes of a mutant
defective in Swarming motility PubMed
defective in the assembly of the flagellar hook PubMed
The protein
Structure
P40405 (AlphaFold)
Localization
membrane-proximal (Spotty) PubMed
membrane PubMed
localizes as puncta at the membrane in numbers fewer than that of flagellar basal bodies PubMed
Expression and Regulation
Operons
Genes
ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
see fla-che operon
Regulatory mechanism
Spo0A: repression, in spo0A regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SwrA: activation, in swrA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
Open in new tab

ylxF→swrB

2025-04-04 21:21:07

Jstuelk

170

EECFE9022742ECC57D9BBA5CE7DB7A4D1BFD42A8

0535E3D13CBD000A94D62050515BF8D1D5E3F011

Genes
flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
Regulatory mechanism
Spo0A: repression, in spo0A regulon
SwrA: activation, in swrA regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SinR: transcription elongation, binding of the SinR-SlrR heteromer to sites within fliE and fliI results in inhibition of transcription elongation PubMed, in sinR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
Open in new tab

flgB→swrB

2025-04-03 01:56:48

Jstuelk

173

024d59ae468aa14568753f57122b789c39ed6c06

4D920B925DA071AE7390E022B9AB625E40B7B2AC

Genes
sigD-swrB
Description
PubMed
Regulation
see [[fla-che operon]]
Open in new tab

sigD→swrB

2025-03-18 11:30:38

ghost

140

d3eeeee2dc606158094f76d4ddfb4359d48bbd59

593BC06DC286D7581D8F55930EC8103A3F86517D

Biological materials
Mutant
MGNA-B082 (ylxL::erm), available at the NBRP B. subtilis, Japan
BKE16480 (swrB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTTTTCACTCGCTAAC,  downstream forward: _UP4_TGATTGTCGGATAAAGCTGT
BKK16480 (swrB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTTTTCACTCGCTAAC,  downstream forward: _UP4_TGATTGTCGGATAAAGCTGT
References
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347ACF1D4E2D0C1B4E9DF0DEA9807A6A7D1519AC

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Time of last update: 2025-04-03 12:57:19

Author of last update: Jstuelk