fin

fin
168

RNA polymerase-binding protein, feedback inhibitor of SigF activity

Locus
BSU_00540
Molecular weight
8.71 kDa
Isoelectric point
5.19
Protein length
76 aaSequenceBlast
Gene length
231 bpSequenceBlast
Function
control of sporulation
Product
feedback inhibitor of SigF activity
Essential
no
Synonyms
fin, subA, yabK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5867 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
60,130 → 60,360
Phenotypes of a mutant
sporulation defect (50-fold reduction of viable spore count) and arrest after engulfment PubMed
The protein
Catalyzed reaction/ biological activity
binding of Fin to the SS' subunit of RNA polymerase prevents binding of SigF, and thus SigF-dependent transcription PubMed
Structure
5MSL (PDB) PubMed
P37553 (AlphaFold)
Localization
localizes diffusely within the forespore compartment of sporangia at both early and late stages of sporulation, cytosolic protein PubMed
Expression and Regulation
Operons
Genes
fin
Description
PubMed
Regulation
expressed in two waves in the forespore (after two hours (SigF) and three hours (SigG) after the onset of sporulation) PubMed
Sigma factors
SigF: sigma factor, PubMed, in sigF regulon
SigG: sigma factor, PubMed, in sigG regulon
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fin

2025-03-18 13:46:07

Bzhu

65

bcf3c9549964b6ecb1ed096e95c30808a00f7093

7D891C8549D6822402F28D08CD55AB5A25848366

Genes
ctc-pth-fin
Description
PubMed
Regulation
induced under stress conditions (SigB) PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
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ctc→fin

2025-04-06 07:31:13

Jstuelk

126

042d8e5a6f42561738123d446c8cdfdcb7b024b0

AF90CE02D929F6F737FC233892E7E08A4B249DEC

Genes
fin-mfd-spoVT
Description
PubMed
Expression
expression is heterogeneous PubMed
Open in new tab

fin→spoVT

2025-04-06 17:53:06

Jstuelk

143

24843A2E745DD5C1C92792486D51FED74A35A094

F1FF2D64FF9C8F7A797DEED100A7732A06763FB4

Biological materials
Mutant
MGNA-B913 (yabK::erm), available at the NBRP B. subtilis, Japan
BKE00540 (Δfin::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACAAGGGTCCTCCTGAT,  downstream forward: _UP4_TAAAAAGCTTTGGTGTAGAC
BKK00540 (Δfin::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACAAGGGTCCTCCTGAT,  downstream forward: _UP4_TAAAAAGCTTTGGTGTAGAC
References
Reviews
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Original Publications
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C595D32D98723E93AF26B5C864FD61AF4739E069

Page visits: 2313

Time of last update: 2025-04-08 13:57:44

Author of last update: Jstuelk