fnr

fnr
168

transcriptional regulator of anaerobic genes

Locus
BSU_37310
Molecular weight
27.07 kDa
Isoelectric point
5.99
Protein length
238 aaSequenceBlast
Gene length
717 bpSequenceBlast
Function
regulation of anaerobiosis, fermentation and overflow metabolism
Product
transcription regulator (Crp family)
Essential
no
Synonyms
fnr
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0664 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,831,512  3,832,228
The protein
Domains
HTH crp-type domain (aa 145-219) (according to UniProt)
Cofactors
[4Fe-4S] cluster PubMed
Structure
P46908 (AlphaFold)
Effectors of protein activity
contains an iron-sulfur cluster
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
fnr
Description
PubMed
Regulation
''fnr'': expressed under anaerobic conditions (ResD) PubMed
Regulatory mechanism
ResD: activation, PubMed, in resD regulon
NsrR: repression, PubMed, in nsrR regulon
Fnr: activation, PubMed, in fnr regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

fnr

2025-04-05 21:57:29

ghost

71

fb9a04e01cb7ce25a7b9cf11ff636da30f848683

3E6FD5E26CEF0ED60159DFE03B533A4F29CECEE2

Genes
narK-fnr
Description
PubMed
Regulation
''fnr'': expressed under anaerobic conditions (ResD) PubMed
Regulatory mechanism
NsrR: repression, PubMed, in nsrR regulon
Fnr: activation, PubMed, in fnr regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

narK→fnr

2025-03-01 04:36:58

ghost

81

238eac5527cfa8f31180009dd7b1e3d43c4bab0b

E61DAB2E4E2621BE034FA4B91DC19527F039482C

Biological materials
Mutant
BKE37310 (fnr::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAGCTCACCTCGAAGAA,  downstream forward: _UP4_TGAAAAAAACAAGGACAGCG
BKK37310 (fnr::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAGCTCACCTCGAAGAA,  downstream forward: _UP4_TGAAAAAAACAAGGACAGCG
References
Reviews
Loading
Other original publications
Loading
The Fnr regulon
Loading

7165CC59CDAF64AAE2D591936860304A53BE5DF6

Page visits: 5116

Time of last update: 2025-04-05 14:15:40

Author of last update: Melvin.boenninger