hisS

hisS
168

histidyl-tRNA synthetase

Locus
BSU_27560
Molecular weight
47.97 kDa
Isoelectric point
5.23
Protein length
424 aaSequenceBlast
Gene length
1275 bpSequenceBlast
Function
translation
Product
histidyl-tRNA synthetase
Essential
yes
E.C.
6.1.1.21
Synonyms
hisS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0124 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,816,535  2,817,809
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
ATP + L-histidine + tRNAHis --> AMP + diphosphate + H+ + L-histidyl-tRNAHis (according to UniProt)
Protein family
Class-II aminoacyl-tRNA synthetase family (according to UniProt)
Structure
1H4V (PDB) (from Thermus thermophilus, 43% identity, 61% similarity) PubMed
O32039 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
hisS-aspS
Regulation
induced by histidine or aspartate limitation (T-box) PubMed
the T-box RNA is degraded by RNase Y PubMed
Regulatory mechanism
T-box: RNA switch, via tRNA controlled RNA switch, in T-box
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hisS→aspS

2025-03-15 12:15:29

Jstuelk

88

93588a5ea574db697b96bea0c2bb438af53f1051

2E078F834F39052D1FF1E957F712D4887C9079D3

References
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69C7EF7E76821FF3D9E866838B24C3866CA9C189

Page visits: 2723

Time of last update: 2025-04-03 22:54:38

Author of last update: Jstuelk