desR

desR
168

two-component response regulator, regulation of cold shock expression of des

Locus
BSU_19200
Molecular weight
22.03 kDa
Isoelectric point
4.89
Protein length
199 aaSequenceBlast
Gene length
600 bpSequenceBlast
Function
regulation of cold shock expression of des
Product
two-component response regulator
Essential
no
Synonyms
desR, yocG
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2197 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,091,705 → 2,092,304
The protein
Catalyzed reaction/ biological activity
transcription activation of the ''des'' operon when phosphorylated by DesK
Domains
Response regulatory domain (aa 3-117) (according to UniProt)
HTH luxR-type domain (aa 131-196) (according to UniProt)
Structure
5IUJ (PDB) (DesK-DesR complex in the phosphotransfer state with low Mg2+ [20 mM]) PubMed
5IUK (PDB) (DesK-DesR complex in the phosphotransfer state with high Mg2+ [150 mM] and BeF3) PubMed
5IUN (PDB) (DesK-DesR complex in the phosphatase state) PubMed
O34723 (AlphaFold)
Modification
phosphorylated by DesK on an Asp residue
Paralogous protein(s)
YvfU
Expression and Regulation
Operons
Genes
desK-desR
Description
PubMed
Regulation
induced by cold shock (12-fold) PubMed
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desK→desR

2025-02-27 16:09:56

ghost

84

25b9128a8b7f56b50905080b061f40a8b0014210

F2EF1E99AB7B6CD97A042B3BC67273F913364739

Biological materials
Mutant
MGNA-A320 (yocG::erm), available at the NBRP B. subtilis, Japan
BKE19200 (ΔdesR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AATCATATAAGCCATCCTTT,  downstream forward: _UP4_TAAAAAAGGATCTTGGCATC
BKK19200 (ΔdesR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AATCATATAAGCCATCCTTT,  downstream forward: _UP4_TAAAAAAGGATCTTGGCATC
Labs working on this gene/protein
Diego de Mendoza, Universidad Nacional de Rosario, Argentine homepage
References
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Time of last update: 2025-04-01 14:08:42

Author of last update: Jstuelk