fapR
168

repressor of fatty acid synthetic genes

Locus

BSU_15880

Molecular weight

21.26 kDa

Isoelectric point

5.39

Protein length

188 aaSequenceBlast

Gene length

567 bpSequenceBlast

Function

regulation of fatty acid biosynthesis

Product

transcriptional repressor

Essential

Synonyms

fapR, ylpC

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2050 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,661,967 → 1,662,533

Additional information

ponA ecsA, ponA sigI, and ponA rasP double mutants have a growth defect that can be suppressed by reduced fatty acid synthesis (mutations in accA, accB, accC, accD or downregulation of the FapR regulon due to specific mutations in fapR) PubMed

The protein

Catalyzed reaction/ biological activity

FapR regulates the expression of at least 10 genes (the fap regulon). It autoregulates its own expression. Malonyl-CoA, a precursor of fatty acid biosynthesis, binds to FapR changing its conformation to a non-DNA binding state. Hence, conditions that cause malonyl-CoA accumulation, like fatty acid biosynthesis inhibition, derepress the fap regulon.

Protein family

fapR family (single member, according to UniProt)

Structure

2F3X (PDB) (complex with effector), 2F41 (PDB) PubMed

O34835 (AlphaFold)

Effectors of protein activity

malonyl-CoA and malonyl-ACP]] act as the molecular inducer of the FapR regulon PubMed

Expression and Regulation

Operons

Genes

fapR-plsX-fabD-fabG-acpA

Description