thiS

thiS
168

sulfur carrier protein, hydroxyethylthiazole phosphate biosynthesis

Locus
BSU_11680
Molecular weight
7.49 kDa
Isoelectric point
5.5
Protein length
66 aaSequenceBlast
Gene length
201 bpSequenceBlast
Function
biosynthesis of thiamine
Product
sulfur carrier protein
Essential
no
E.C.
null
Synonyms
thiS, yjbS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2104 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,244,844  1,245,044
The protein
Protein family
sulfur carrier protein ThiS family (single member, according to UniProt)
Structure
1TYG (PDB) (complex with ThiG) PubMed
O31617 (AlphaFold)
Expression and Regulation
Operons
Genes
tenA-tenI-thiO-thiS-thiG-thiF-thiD
Description
PubMed
Regulation
repressed by thiamine (Thi-box) PubMed
antitermination is modulated by NusG-dependent transcription pausing just upstream of the Thi-box PubMed
the Thi-box RNA is degraded by RNase Y PubMed
Regulatory mechanism
Thi-box: RNA switch, via RNA switch, in Thi-box regulon
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tenA→thiD

2025-04-03 13:11:27

Jstuelk

127

A48634F4963321F6F5F59C5107F472325227A1B0

A1FEA45B91FD65F137EB4D1A0FCD88BC91331EAF

Biological materials
Mutant
BKE11680 (thiS::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTCTTTACCGTTCAGCTGTA,  downstream forward: _UP4_ATTGTCCATTTTGTAGGAGG
BKK11680 (thiS::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTCTTTACCGTTCAGCTGTA,  downstream forward: _UP4_ATTGTCCATTTTGTAGGAGG
References
Reviews
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Original Publications
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95DA3F899037140F48B99E065C768356CE08FA94

Page visits: 2065

Time of last update: 2025-04-03 13:44:30

Author of last update: Melvin.boenninger