fabHB

fabHB
168

beta-ketoacyl-acyl carrier protein synthase III

Locus
BSU_10170
Molecular weight
35.27 kDa
Isoelectric point
5.68
Protein length
325 aaSequenceBlast
Gene length
978 bpSequenceBlast
Function
fatty acid biosynthesis
Product
beta-ketoacyl-acyl carrier protein synthase III
Essential
no
E.C.
2.3.1.180
Synonyms
fabHB, yhfB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0332 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,092,770 → 1,093,747
The protein
Catalyzed reaction/ biological activity
acetyl-CoA + H+ + malonyl-[ACP] --> 3-oxobutanoyl-[ACP] + CO2 + CoA (according to UniProt)
Protein family
thiolase-like superfamily (according to UniProt)
Structure
8VDB (PDB) PubMed
O07600 (AlphaFold)
Paralogous protein(s)
FabHA, one of the two proteins has to be present for viability PubMed
Localization
cytoplasm (according to Swiss-Prot)
Additional information
affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis PubMed
Expression and Regulation
Operons
Genes
fabHB
Description
PubMed
Regulation
induced if the cells experience a lack of malonyl-CoA (FapR) PubMed
Regulatory mechanism
FapR: repression, PubMed, in fapR regulon
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fabHB

2025-03-15 04:24:10

ghost

66

b2a2c91bc5ac9eb107345d5e16a670ae08aec7c1

A4E5F338DA5C7FD67B4407C6853E9B940ED4034E

Biological materials
Mutant
BKE10170 (ΔfabHB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGAATCACTCCTTATG,  downstream forward: _UP4_TAACAAAAAAAGAACTTGTT
BKK10170 (ΔfabHB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGAATCACTCCTTATG,  downstream forward: _UP4_TAACAAAAAAAGAACTTGTT
References
Reviews
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Original Publications
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Page visits: 3620

Time of last update: 2025-04-18 23:38:19

Author of last update: Jstuelk