AppA

• Description: oligopeptide ABC transporter (peptide-binding protein)
  
  

Gene name	appA
Synonyms
Essential	no
Product	oligopeptide ABC transporter (peptide-binding protein))
Function	uptake of oligopeptides
MW, pI	61 kDa, 5.733
Gene length, protein length	1629 bp, 543 aa
Immediate neighbours	appF, appB
Gene sequence (+200bp)	Protein sequence
Caution: The sequence for this gene in SubtiList contains errors
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 1XOC (complex with nonapeptide)

• Swiss prot entry: P42061

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: appD-appF-appA-appB-appC

• Sigma factor:

• Regulation: repressed by casamino acids PubMed, repressed by CodY PubMed

• Regulatory mechanism: CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Tony Wilkinson, York University, U.K. homepage

References

1. Mäder et al. (2002) Transcriptome and Proteome Analysis of Bacillus subtilis Gene Expression Modulated by Amino Acid Availability. J. Bacteriol 184: 1844288-4295 PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed