Stusti 2018
Contents
- 1 Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
- 1.1 What makes RNA such a special molecule – specific chemical and structural features of RNA
- 1.2 RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
- 1.3 Ribozymes (catalytically active RNAs)
- 1.3.1 The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
- 1.3.2 The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
- 1.3.3 Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.
- 1.4 RNA-based second messengers
- 1.5 Riboregulation and virulence, targeting by antibiotics
- 1.6 Riboswitches
- 1.7 Protein- or tRNA-controlled RNA switches
- 1.8 RNA thermometers
- 1.9 The RNA world and evolution
- 1.10 RNA modification
- 1.11 RNA degradation/processing
- 1.12 Regulation by non-coding RNA
- 1.13 RNAs as essential co-factors in protein enzymes
- 1.13.1 RNA dependent DNA Polymerases - from telomerase to retroviruses
- 1.13.2 RNA dependent RNA Polymerases – the RNA replicase
- 1.13.3 CRISPR/Cas: Science – the bacterial “immune” system
- 1.13.4 CRISPR/Cas: Application and groundbreaking perspectives
- 1.13.5 The mysterious function and role of 6S-RNA and pRNA in bacteria
- 1.14 Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
- 1.15 Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
- 1.16 Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
What makes RNA such a special molecule – specific chemical and structural features of RNA
David A Hiller, Scott A Strobel
The chemical versatility of RNA.
Philos Trans R Soc Lond B Biol Sci: 2011, 366(1580);2929-35
[PubMed:21930584]
[WorldCat.org]
[DOI]
(I p)
RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
Ribozymes (catalytically active RNAs)
The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
Meredith Root-Bernstein, Robert Root-Bernstein
The ribosome as a missing link in the evolution of life.
J Theor Biol: 2015, 367;130-158
[PubMed:25500179]
[WorldCat.org]
[DOI]
(I p)
Ingo Wohlgemuth, Corinna Pohl, Joerg Mittelstaet, Andrey L Konevega, Marina V Rodnina
Evolutionary optimization of speed and accuracy of decoding on the ribosome.
Philos Trans R Soc Lond B Biol Sci: 2011, 366(1580);2979-86
[PubMed:21930591]
[WorldCat.org]
[DOI]
(I p)
Thomas A Steitz
A structural understanding of the dynamic ribosome machine.
Nat Rev Mol Cell Biol: 2008, 9(3);242-53
[PubMed:18292779]
[WorldCat.org]
[DOI]
(I p)
The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.
RNA-based second messengers
Riboregulation and virulence, targeting by antibiotics
Riboswitches
Protein- or tRNA-controlled RNA switches
RNA thermometers
The RNA world and evolution
RNA modification
RNA degradation/processing
Regulation by non-coding RNA
RNAs as essential co-factors in protein enzymes
RNA dependent DNA Polymerases - from telomerase to retroviruses
RNA dependent RNA Polymerases – the RNA replicase
CRISPR/Cas: Science – the bacterial “immune” system
CRISPR/Cas: Application and groundbreaking perspectives
The mysterious function and role of 6S-RNA and pRNA in bacteria
Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
