Stusti 2018
Contents
- 1 Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
- 1.1 What makes RNA such a special molecule – specific chemical and structural features of RNA
- 1.2 RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
- 1.3 Ribozymes (catalytically active RNAs)
- 1.3.1 The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
- 1.3.2 The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
- 1.3.3 Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.
- 1.4 RNA-based second messengers
- 1.5 Riboregulation and virulence, targeting by antibiotics
- 1.6 Riboswitches
- 1.7 Protein- or tRNA-controlled RNA switches
- 1.8 RNA thermometers
- 1.9 The RNA world and evolution
- 1.10 RNA modification
- 1.11 RNA degradation/processing
- 1.12 Regulation by non-coding RNA
- 1.13 RNAs as essential co-factors in protein enzymes
- 1.13.1 RNA dependent DNA Polymerases - from telomerase to retroviruses
- 1.13.2 RNA dependent RNA Polymerases – the RNA replicase
- 1.13.3 CRISPR/Cas: Science – the bacterial “immune” system
- 1.13.4 CRISPR/Cas: Application and groundbreaking perspectives
- 1.13.5 The mysterious function and role of 6S-RNA and pRNA in bacteria
- 1.14 Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
- 1.15 Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
- 1.16 Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
What makes RNA such a special molecule – specific chemical and structural features of RNA
RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
Ribozymes (catalytically active RNAs)
The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.
RNA-based second messengers
Riboregulation and virulence, targeting by antibiotics
Riboswitches
Protein- or tRNA-controlled RNA switches
RNA thermometers
The RNA world and evolution
RNA modification
RNA degradation/processing
Regulation by non-coding RNA
RNAs as essential co-factors in protein enzymes
RNA dependent DNA Polymerases - from telomerase to retroviruses
RNA dependent RNA Polymerases – the RNA replicase
CRISPR/Cas: Science – the bacterial “immune” system
CRISPR/Cas: Application and groundbreaking perspectives
Addison V Wright, James K Nuñez, Jennifer A Doudna
Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering.
Cell: 2016, 164(1-2);29-44
[PubMed:26771484]
[WorldCat.org]
[DOI]
(I p)
The mysterious function and role of 6S-RNA and pRNA in bacteria
Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
Shahnaz Haque, Lorna W Harries
Circular RNAs (circRNAs) in Health and Disease.
Genes (Basel): 2017, 8(12);
[PubMed:29182528]
[WorldCat.org]
[DOI]
(P e)
Feng Liu
Enhancer-derived RNA: A Primer.
Genomics Proteomics Bioinformatics: 2017, 15(3);196-200
[PubMed:28533025]
[WorldCat.org]
[DOI]
(I p)
Kuei-Yang Hsiao, H Sunny Sun, Shaw-Jenq Tsai
Circular RNA - New member of noncoding RNA with novel functions.
Exp Biol Med (Maywood): 2017, 242(11);1136-1141
[PubMed:28485684]
[WorldCat.org]
[DOI]
(I p)
Yiwen Fang, Melissa J Fullwood
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer.
Genomics Proteomics Bioinformatics: 2016, 14(1);42-54
[PubMed:26883671]
[WorldCat.org]
[DOI]
(I p)
Tae-Kyung Kim, Martin Hemberg, Jesse M Gray
Enhancer RNAs: a class of long noncoding RNAs synthesized at enhancers.
Cold Spring Harb Perspect Biol: 2015, 7(1);a018622
[PubMed:25561718]
[WorldCat.org]
[DOI]
(I e)
Kevin C Wang, Howard Y Chang
Molecular mechanisms of long noncoding RNAs.
Mol Cell: 2011, 43(6);904-14
[PubMed:21925379]
[WorldCat.org]
[DOI]
(I p)
Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
