Stusti 2018
Contents
- 1 Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
- 1.1 What makes RNA such a special molecule – specific chemical and structural features of RNA
- 1.2 RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
- 1.3 Ribozymes (catalytically active RNAs)
- 1.3.1 The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
- 1.3.2 The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
- 1.3.3 Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.
- 1.4 RNA-based second messengers
- 1.5 Riboregulation and virulence, targeting by antibiotics
- 1.6 Riboswitches
- 1.7 Protein- or tRNA-controlled RNA switches
- 1.8 RNA thermometers
- 1.9 The RNA world and evolution
- 1.10 RNA modification
- 1.11 RNA degradation/processing
- 1.12 Regulation by non-coding RNA
- 1.13 RNAs as essential co-factors in protein enzymes
- 1.13.1 RNA dependent DNA Polymerases - from telomerase to retroviruses
- 1.13.2 RNA dependent RNA Polymerases – the RNA replicase
- 1.13.3 CRISPR/Cas: Science – the bacterial “immune” system
- 1.13.4 CRISPR/Cas: Application and groundbreaking perspectives
- 1.13.5 The mysterious function and role of 6S-RNA and pRNA in bacteria
- 1.14 Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
- 1.15 Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
- 1.16 Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
What makes RNA such a special molecule – specific chemical and structural features of RNA
RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
Ribozymes (catalytically active RNAs)
The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
Panagiotis Papasaikas, Juan Valcárcel
The Spliceosome: The Ultimate RNA Chaperone and Sculptor.
Trends Biochem Sci: 2016, 41(1);33-45
[PubMed:26682498]
[WorldCat.org]
[DOI]
(I p)
Yan Wang, Jing Liu, B O Huang, Yan-Mei Xu, Jing Li, Lin-Feng Huang, Jin Lin, Jing Zhang, Qing-Hua Min, Wei-Ming Yang, Xiao-Zhong Wang
Mechanism of alternative splicing and its regulation.
Biomed Rep: 2015, 3(2);152-158
[PubMed:25798239]
[WorldCat.org]
[DOI]
(P p)
A Gregory Matera, Zefeng Wang
A day in the life of the spliceosome.
Nat Rev Mol Cell Biol: 2014, 15(2);108-21
[PubMed:24452469]
[WorldCat.org]
[DOI]
(I p)
Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.
Christian Hammann, Andrej Luptak, Jonathan Perreault, Marcos de la Peña
The ubiquitous hammerhead ribozyme.
RNA: 2012, 18(5);871-85
[PubMed:22454536]
[WorldCat.org]
[DOI]
(I p)
Sidney Altman
Ribonuclease P.
Philos Trans R Soc Lond B Biol Sci: 2011, 366(1580);2936-41
[PubMed:21930585]
[WorldCat.org]
[DOI]
(I p)
David M J Lilley
The Varkud satellite ribozyme.
RNA: 2004, 10(2);151-8
[PubMed:14730013]
[WorldCat.org]
[DOI]
(P p)
R Shippy, R Lockner, M Farnsworth, A Hampel
The hairpin ribozyme. Discovery, mechanism, and development for gene therapy.
Mol Biotechnol: 1999, 12(1);117-29
[PubMed:10554775]
[WorldCat.org]
[DOI]
(P p)
K Kruger, P J Grabowski, A J Zaug, J Sands, D E Gottschling, T R Cech
Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
Cell: 1982, 31(1);147-57
[PubMed:6297745]
[WorldCat.org]
[DOI]
(P p)
RNA-based second messengers
Riboregulation and virulence, targeting by antibiotics
Riboswitches
Protein- or tRNA-controlled RNA switches
RNA thermometers
The RNA world and evolution
Ádám Kun, Ádám Radványi
The evolution of the genetic code: Impasses and challenges.
Biosystems: 2018, 164;217-225
[PubMed:29031737]
[WorldCat.org]
[DOI]
(I p)
Thomas Fouqueau, Fabian Blombach, Finn Werner
Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation.
Annu Rev Microbiol: 2017, 71;331-348
[PubMed:28657884]
[WorldCat.org]
[DOI]
(I p)
Abe Pressman, Celia Blanco, Irene A Chen
The RNA World as a Model System to Study the Origin of Life.
Curr Biol: 2015, 25(19);R953-63
[PubMed:26439358]
[WorldCat.org]
[DOI]
(I p)
Jessica C Bowman, Nicholas V Hud, Loren Dean Williams
The ribosome challenge to the RNA world.
J Mol Evol: 2015, 80(3-4);143-61
[PubMed:25739364]
[WorldCat.org]
[DOI]
(I p)
Daniel Lundin, Gustav Berggren, Derek T Logan, Britt-Marie Sjöberg
The origin and evolution of ribonucleotide reduction.
Life (Basel): 2015, 5(1);604-36
[PubMed:25734234]
[WorldCat.org]
[DOI]
(P e)
Paul G Higgs, Niles Lehman
The RNA World: molecular cooperation at the origins of life.
Nat Rev Genet: 2015, 16(1);7-17
[PubMed:25385129]
[WorldCat.org]
[DOI]
(I p)
Markus Ralser
The RNA world and the origin of metabolic enzymes.
Biochem Soc Trans: 2014, 42(4);985-8
[PubMed:25109990]
[WorldCat.org]
[DOI]
(I p)
Eugene V Koonin, Artem S Novozhilov
Origin and evolution of the genetic code: the universal enigma.
IUBMB Life: 2009, 61(2);99-111
[PubMed:19117371]
[WorldCat.org]
[DOI]
(I p)
Yuri I Wolf, Eugene V Koonin
On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization.
Biol Direct: 2007, 2;14
[PubMed:17540026]
[WorldCat.org]
[DOI]
(I e)
RNA modification
RNA degradation/processing
Regulation by non-coding RNA
RNAs as essential co-factors in protein enzymes
RNA dependent DNA Polymerases - from telomerase to retroviruses
RNA dependent RNA Polymerases – the RNA replicase
CRISPR/Cas: Science – the bacterial “immune” system
CRISPR/Cas: Application and groundbreaking perspectives
The mysterious function and role of 6S-RNA and pRNA in bacteria
Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways