Stusti 2018

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Contents

Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas

What makes RNA such a special molecule – specific chemical and structural features of RNA


RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair


Ribozymes (catalytically active RNAs)


The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology


The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity

Panagiotis Papasaikas, Juan Valcárcel
The Spliceosome: The Ultimate RNA Chaperone and Sculptor.
Trends Biochem Sci: 2016, 41(1);33-45
[PubMed:26682498] [WorldCat.org] [DOI] (I p)

Yan Wang, Jing Liu, B O Huang, Yan-Mei Xu, Jing Li, Lin-Feng Huang, Jin Lin, Jing Zhang, Qing-Hua Min, Wei-Ming Yang, Xiao-Zhong Wang
Mechanism of alternative splicing and its regulation.
Biomed Rep: 2015, 3(2);152-158
[PubMed:25798239] [WorldCat.org] [DOI] (P p)

A Gregory Matera, Zefeng Wang
A day in the life of the spliceosome.
Nat Rev Mol Cell Biol: 2014, 15(2);108-21
[PubMed:24452469] [WorldCat.org] [DOI] (I p)


Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme and Co.

Christian Hammann, Andrej Luptak, Jonathan Perreault, Marcos de la Peña
The ubiquitous hammerhead ribozyme.
RNA: 2012, 18(5);871-85
[PubMed:22454536] [WorldCat.org] [DOI] (I p)

Sidney Altman
Ribonuclease P.
Philos Trans R Soc Lond B Biol Sci: 2011, 366(1580);2936-41
[PubMed:21930585] [WorldCat.org] [DOI] (I p)

David M J Lilley
The Varkud satellite ribozyme.
RNA: 2004, 10(2);151-8
[PubMed:14730013] [WorldCat.org] [DOI] (P p)

R Shippy, R Lockner, M Farnsworth, A Hampel
The hairpin ribozyme. Discovery, mechanism, and development for gene therapy.
Mol Biotechnol: 1999, 12(1);117-29
[PubMed:10554775] [WorldCat.org] [DOI] (P p)

K Kruger, P J Grabowski, A J Zaug, J Sands, D E Gottschling, T R Cech
Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
Cell: 1982, 31(1);147-57
[PubMed:6297745] [WorldCat.org] [DOI] (P p)


RNA-based second messengers


Riboregulation and virulence, targeting by antibiotics


Riboswitches


Protein- or tRNA-controlled RNA switches


RNA thermometers


The RNA world and evolution

Ádám Kun, Ádám Radványi
The evolution of the genetic code: Impasses and challenges.
Biosystems: 2018, 164;217-225
[PubMed:29031737] [WorldCat.org] [DOI] (I p)

Thomas Fouqueau, Fabian Blombach, Finn Werner
Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation.
Annu Rev Microbiol: 2017, 71;331-348
[PubMed:28657884] [WorldCat.org] [DOI] (I p)

Abe Pressman, Celia Blanco, Irene A Chen
The RNA World as a Model System to Study the Origin of Life.
Curr Biol: 2015, 25(19);R953-63
[PubMed:26439358] [WorldCat.org] [DOI] (I p)

Jessica C Bowman, Nicholas V Hud, Loren Dean Williams
The ribosome challenge to the RNA world.
J Mol Evol: 2015, 80(3-4);143-61
[PubMed:25739364] [WorldCat.org] [DOI] (I p)

Daniel Lundin, Gustav Berggren, Derek T Logan, Britt-Marie Sjöberg
The origin and evolution of ribonucleotide reduction.
Life (Basel): 2015, 5(1);604-36
[PubMed:25734234] [WorldCat.org] [DOI] (P e)

Paul G Higgs, Niles Lehman
The RNA World: molecular cooperation at the origins of life.
Nat Rev Genet: 2015, 16(1);7-17
[PubMed:25385129] [WorldCat.org] [DOI] (I p)

Markus Ralser
The RNA world and the origin of metabolic enzymes.
Biochem Soc Trans: 2014, 42(4);985-8
[PubMed:25109990] [WorldCat.org] [DOI] (I p)

Eugene V Koonin, Artem S Novozhilov
Origin and evolution of the genetic code: the universal enigma.
IUBMB Life: 2009, 61(2);99-111
[PubMed:19117371] [WorldCat.org] [DOI] (I p)

Yuri I Wolf, Eugene V Koonin
On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization.
Biol Direct: 2007, 2;14
[PubMed:17540026] [WorldCat.org] [DOI] (I e)


RNA modification


RNA degradation/processing


Regulation by non-coding RNA



RNAs as essential co-factors in protein enzymes

RNA dependent DNA Polymerases - from telomerase to retroviruses


RNA dependent RNA Polymerases – the RNA replicase


CRISPR/Cas: Science – the bacterial “immune” system


CRISPR/Cas: Application and groundbreaking perspectives


The mysterious function and role of 6S-RNA and pRNA in bacteria


Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer


Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)


Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways