Stusti 2018

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Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas

Riboswitches


Riboregulation and virulence, targeting by antibiotics


RNA-based second messengers


Ribozymes


Protein- or tRNA-controlled RNA switches

Jinwei Zhang, Adrian R Ferré-D'Amaré
Structure and mechanism of the T-box riboswitches.
Wiley Interdiscip Rev RNA: 2015, 6(4);419-33
[PubMed:25959893] [WorldCat.org] [DOI] (I p)

Anna V Sherwood, Frank J Grundy, Tina M Henkin
T box riboswitches in Actinobacteria: translational regulation via novel tRNA interactions.
Proc Natl Acad Sci U S A: 2015, 112(4);1113-8
[PubMed:25583497] [WorldCat.org] [DOI] (I p)

Tina M Henkin
The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand.
Biochim Biophys Acta: 2014, 1839(10);959-963
[PubMed:24816551] [WorldCat.org] [DOI] (P p)


RNA thermometers

Satya Narayan, Mamta H Kombrabail, Sudipta Das, Himanshu Singh, Kandala V R Chary, Basuthkar J Rao, Guruswamy Krishnamoorthy
Site-specific fluorescence dynamics in an RNA 'thermometer' reveals the role of ribosome binding in its temperature-sensitive switch function.
Nucleic Acids Res: 2015, 43(1);493-503
[PubMed:25477380] [WorldCat.org] [DOI] (I p)


The RNA world and evolution

Ádám Kun, Ádám Radványi
The evolution of the genetic code: Impasses and challenges.
Biosystems: 2018, 164;217-225
[PubMed:29031737] [WorldCat.org] [DOI] (I p)

Thomas Fouqueau, Fabian Blombach, Finn Werner
Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation.
Annu Rev Microbiol: 2017, 71;331-348
[PubMed:28657884] [WorldCat.org] [DOI] (I p)

Randi M Jimenez, Julio A Polanco, Andrej Lupták
Chemistry and Biology of Self-Cleaving Ribozymes.
Trends Biochem Sci: 2015, 40(11);648-661
[PubMed:26481500] [WorldCat.org] [DOI] (I p)

Eugene V Koonin, Artem S Novozhilov
Origin and evolution of the genetic code: the universal enigma.
IUBMB Life: 2009, 61(2);99-111
[PubMed:19117371] [WorldCat.org] [DOI] (I p)

Yuri I Wolf, Eugene V Koonin
On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization.
Biol Direct: 2007, 2;14
[PubMed:17540026] [WorldCat.org] [DOI] (I e)


RNA modification


RNA degradation/ processing


CRISPR/Cas: Science



CRISPR/Cas: Application