mcpC

mcpC
168

membrane-bound chemotaxis receptor for proline, methyl-accepting chemotaxis protein

Locus
BSU_13950
Molecular weight
71.93 kDa
Isoelectric point
5.17
Protein length
655 aaSequenceBlast
Gene length
1968 bpSequenceBlast
Function
control of chemotaxis to proline, threonine, glycine, serine, lysine, valine and arginine
Product
methyl-accepting chemotaxis protein
Essential
no
Synonyms
mcpC, prg71
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0840 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,463,628  1,465,595
The protein
Catalyzed reaction/ biological activity
deaminated McpC stimulates phosphorylation of CheA PubMed
responsible for attractant response towards phenol and other aromatics at low (micromolar) concentrations PubMed
Domains
Cache domain (aa 148-225) (according to UniProt)
HAMP domain (aa 298-350) (according to UniProt)
Methyl-accepting transducer domain (aa 369-619) (according to UniProt)
Structure
6S1K (PDB) (from E. coli, corresponds to aa 279 ... 593, 26% identity) PubMed
P54576 (AlphaFold)
Modification
deamination of Gln-609 (by CheD) PubMed, deaminated McpC stimulates phosphorylation of CheA PubMed
Paralogous protein(s)
McpB, McpA, TlpA, TlpB
Localization
cell membrane PubMed
Expression and Regulation
Operons
Genes
mcpC
Description
PubMed
Sigma factors
SigD: sigma factor, PubMed, in sigD regulon
Additional information
in minimal medium, McpC is present with 2,800 /- 640 molecules per cell PubMed
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mcpC

2025-04-07 19:08:16

ghost

94

0d33f32e8e0d88b1c29b3fc4906b5afd83edd958

08CBD29FF4F4B939A75DF93779E0C29E04F48E1D

Biological materials
Mutant
DS180 (mcpC::mls in NCIB3610) PubMed
BKE13950 (mcpC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAACCAATCCCCTCCTAAT,  downstream forward: _UP4_TAATCCAATTACATCCCCAA
BKK13950 (mcpC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAACCAATCCCCTCCTAAT,  downstream forward: _UP4_TAATCCAATTACATCCCCAA
References
Reviews
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Original Publications
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8333CD46F704F03A22482CAA98DEFCC945362A10

Page visits: 4468

Time of last update: 2025-04-07 22:43:26

Author of last update: Jstuelk