luxS

luxS
168

S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for surface spreading motility (sliding) of B. subtilis natto and biofilm formation

Locus
BSU_30670
Molecular weight
17.57 kDa
Isoelectric point
5.17
Protein length
157 aaSequenceBlast
Gene length
474 bpSequenceBlast
Function
methionine salvage
Product
S-ribosylhomocysteine lyase
Essential
no
E.C.
4.4.1.21
Synonyms
luxS, ytjB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1854 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,137,495 → 3,137,968
The protein
Catalyzed reaction/ biological activity
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine --> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine (according to UniProt)
Protein family
luxS family (single member, according to UniProt)
Structure
1JQW (PDB) (complex with homocysteine),  1J98 (PDB) PubMed
O34667 (AlphaFold)
Effectors of protein activity
subject to feedback inhibition PubMed
Expression and Regulation
Operons
Genes
luxS
Description
PubMed
Additional information
subject to feedback inhibition PubMed
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luxS

2025-03-29 03:41:55

ghost

63

59bee1682afcc081acd66ba477e9635f5dfb1281

503FE72136AE4E3F3B14AB8F32C7ACC0CEFBB288

Genes
ytiB-luxS
Description
PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
Open in new tab

ytiB->luxS

2025-04-03 12:17:23

Bzhu

79

75926799ff2de1c9324aa7def16e549e605f52eb

BC92809DA5580B1417FA8A9D54A26A0EA0ADDFD9

Biological materials
Mutant
MGNA-B540 (ytjB::erm), available at the NBRP B. subtilis, Japan
1A953 ( luxS::cat), PubMed, available at BGSC
BKE30670 (ΔluxS::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAATGGCACTCTCCCCTT,  downstream forward: _UP4_TAAAATAGAAAGGACCTTTT
BKK30670 (ΔluxS::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAATGGCACTCTCCCCTT,  downstream forward: _UP4_TAAAATAGAAAGGACCTTTT
References
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FF61DC6CA162EEC191CDFC802E721FCBD32EC098

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Time of last update: 2025-04-05 15:39:25

Author of last update: Melvin.boenninger