zur

zur
168

transcriptional repressor, regulates zinc homeostasis

Locus
BSU_25100
Molecular weight
16.42 kDa
Isoelectric point
4.86
Protein length
145 aaSequenceBlast
Gene length
438 bpSequenceBlast
Function
regulation of zinc homeostasis(zagA, znuA-znuC-znuB)
Product
transcriptional repressor (Fur family)
Essential
no
Synonyms
zur, yqfV
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0735 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,591,428  2,591,865
The protein
Protein family
Fur family (according to UniProt)
Structure
2FE3 (PDB) (PerR, 35% identity) PubMed
P54479 (AlphaFold)
Modification
phosphorylated on ser/ thr/ tyr PubMed
Effectors of protein activity
sequential binding of zinc (two atoms per monomer) results in the activation of Zur dimer and thus in repression of the genes of the Zur regulon PubMed
zinc binding is negatively co-operative resulting in step-wise induction of the genes of the Zur regulon upon zinc depletion PubMed
Paralogous protein(s)
Fur, PerR
Localization
information on binding sites can be found in the PRODORIC2 database
Expression and Regulation
Operons
Genes
yqfU-zur
Description
PubMed
Open in new tab

yqfU→zur

2025-03-11 03:45:07

Jstuelk

78

ac60bd45458950d863054ce20cc2dd96eb965f7a

70C58CD30FD55FB5EE42DD20610C4696D9D314B6

Biological materials
Mutant
1A904 ( zur::spec), PubMed, available at BGSC
BKE25100 (zur::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAAGGGTCCCCCTTTTC,  downstream forward: _UP4_TAAAATGCGTATATATGAAA
BKK25100 (zur::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAAGGGTCCCCCTTTTC,  downstream forward: _UP4_TAAAATGCGTATATATGAAA
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
References
Reviews
Loading
Original Publications
Loading

A0CD8CCB54AE9F10DE3C876FB47B9877C303862D

Page visits: 6235

Time of last update: 2025-04-02 12:24:59

Author of last update: Jstuelk