Noc

• Description: DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division, Noc and the Min system ensure the efficient utilization of the division site at midcell in by ensuring Z ring placement
  
  

Gene name	noc
Synonyms	yyaA
Essential	no
Product	effector of nucleoid occlusion
Function	control of cell division
Gene expression levels in SubtiExpress: noc
MW, pI	32 kDa, 5.812
Gene length, protein length	849 bp, 283 aa
Immediate neighbours	yyaB, rsmG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU40990

Phenotypes of a mutant

• a yvcL noc double mutant grows poorly, and the cells are filamentous PubMed

Database entries

• BsubCyc: BSU40990

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds specific sites on the chromosome PubMed

• Protein family: ParB family (according to Swiss-Prot)

• Paralogous protein(s): Spo0J

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • associated to the cell membrane PubMed

Database entries

• BsubCyc: BSU40990

• Structure:

• UniProt: P37524

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: thdF-gidA-rsmG-noc PubMed

• Expression browser: noc PubMed

• Sigma factor:

• Regulation:
  • constitutively expressed PubMed

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 382 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 7544 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion: available in the Jeff Errington lab

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jeff Errington, Newcastle, UK Homepage

References

Reviews

Marc Bramkamp, Suey van Baarle
Division site selection in rod-shaped bacteria.
Curr Opin Microbiol: 2009, 12(6);683-8
[PubMed:19884039] [WorldCat.org] [DOI] (I p)

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)