BpsA

• Description: type III polyketide synthase
  
  

Gene name	bpsA
Synonyms	bcsA
Essential	no
Product	type III polyketide synthase
Function	polyketide synthesis
Gene expression levels in SubtiExpress: bpsA
MW, pI	40 kDa, 7.958
Gene length, protein length	1095 bp, 365 aa
Immediate neighbours	bpsB, pbuX
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds, membrane proteins, sporulation proteins

The gene

Basic information

• Locus tag: BSU22050

Database entries

• BsubCyc: BSU22050

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: synthesis of triketide pyrones from long-chain fatty acyl CoA thioesters as starter substrates and malonyl-CoA as an extender substrate PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU22050

• Structure:

• UniProt: P54157

• KEGG entry: [2]

• E.C. number: 2.3.1.74

Expression and regulation

• Operon: bpsA-bpsB PubMed

• Expression browser: bpsA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Chiaki Nakano, Hiroki Ozawa, Genki Akanuma, Nobutaka Funa, Sueharu Horinouchi
Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis.
J Bacteriol: 2009, 191(15);4916-23
[PubMed:19465653] [WorldCat.org] [DOI] (I p)