GlxA

• Description: glyoxalase I
  
  

Gene name	glxA
Synonyms	ipa-18r, ywbC
Essential	no
Product	glyoxalase I
Function	detoxification of methylglyoxal
Gene expression levels in SubtiExpress: glxA
Metabolic function and regulation of this protein in SubtiPathways: glxA
MW, pI	14 kDa, 4.429
Gene length, protein length	378 bp, 126 aa
Immediate neighbours	ywbD, ywbB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against oxidative and electrophile stress

The gene

Basic information

• Locus tag: BSU38370

Phenotypes of a mutant

• increased sensitivity to methylglyoxal PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • methylglyoxal + BSH --> S-lactoyl-bacillithiol (BSH) PubMed

• Protein family: glyoxalase I family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39586

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: glxA PubMed

• Expression browser: glxA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 229 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 3299 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 1387 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 2906 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: