BrxA

• Description: bacilliredoxin
  
  

Gene name	brxA
Synonyms	yphP
Essential	no
Product	bacilliredoxin
Function	de-bacillithiolation of S-bacillithiolated OhrR and MetE
Gene expression levels in SubtiExpress: brxA
Interactions involving this protein in SubtInteract: BrxA
MW, pI	15 kDa, 4.619
Gene length, protein length	432 bp, 144 aa
Immediate neighbours	ypiP, ilvD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against oxidative and electrophile stress

The gene

Basic information

• Locus tag: BSU21860

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • de-bacillithiolation of S-bacillithiolated OhrR and MetE PubMed

• Protein family: scpA family (according to Swiss-Prot)

• Paralogous protein(s): BrxB

Extended information on the protein

• Kinetic information:

• Domains: contains an CxC redox motif [3]

• Modification:
  • S-bacillithiolation upon hypochlorite stress on Cys-53 PubMed

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • BrxA-MetE PubMed
  • BrxA-OhrR PubMed

• Localization:

Database entries

• Structure: 3FHK PubMed

• UniProt: P54170

• KEGG entry: [4]

• E.C. number:

Expression and regulation

• Operon: brxA (according to DBTBS)

• Expression browser: brxA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 730 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 1649 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Your additional remarks

YpdA, BrxA, BrxB and YtxJ co-occur in those species predicted to synthesize bacillithiol.