FrlR

• Description: transcriptional regulator (GntR family)
  
  

Gene name	frlR
Synonyms	yurK
Essential	no
Product	transcriptional regulator (GntR family)
Function	regulation of utilization of sugar amines
Gene expression levels in SubtiExpress: frlR
MW, pI	27 kDa, 6.419
Gene length, protein length	726 bp, 242 aa
Immediate neighbours	yurJ, frlD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, utilization of nitrogen sources other than amino acids, transcription factors and their control

The FrlR regulon:

• frlB-frlO-frlN-frlM-frlD

The gene

Basic information

• Locus tag: BSU32560

Database entries

• BsubCyc: BSU32560

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU32560

• Structure: 2IKK (C-terminal domain)

• UniProt: O32152

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: frlR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 234 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 99 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Veronika Maria Deppe, Stephanie Klatte, Johannes Bongaerts, Karl-Heinz Maurer, Timothy O'Connell, Friedhelm Meinhardt
Genetic control of amadori product degradation in Bacillus subtilis via regulation of frlBONMD expression by FrlR.
Appl Environ Microbiol: 2011, 77(9);2839-46
[PubMed:21398478] [WorldCat.org] [DOI] (I p)

Veronika Maria Deppe, Johannes Bongaerts, Timothy O'Connell, Karl-Heinz Maurer, Friedhelm Meinhardt
Enzymatic deglycation of Amadori products in bacteria: mechanisms, occurrence and physiological functions.
Appl Microbiol Biotechnol: 2011, 90(2);399-406
[PubMed:21347729] [WorldCat.org] [DOI] (I p)