uppS
168

undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

Locus

BSU_16530

Molecular weight

29.63 kDa

Isoelectric point

5.41

Protein length

260 aaSequenceBlast

Gene length

783 bpSequenceBlast

Function

cell wall biosynthesis

Product

undecaprenyl pyrophosphate synthetase

Essential

yes

E.C.

2.5.1.31

Synonyms

uppS, yluA

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0020 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,721,214 1,721,996

Phenotypes of a mutant

essential PubMed

uppS is dispensable in wall-less L-forms PubMed

the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed

inactivation suppresses the essentiality of mbl PubMed

The protein

Catalyzed reaction/ biological activity

catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate

Protein family

UPP synthetase family (single member, according to UniProt)

Structure

1X09 (PDB) (the protein from E. coli, 49% identity, 77% similarity) PubMed

O31751 (AlphaFold)

Expression and Regulation

Operons

Genes

uppS-cdsA-ispC-rasP-proS-polC

Description

PubMed

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