Abh

• Description: transcriptional regulator of transition state genes
  
  

Gene name	abh
Synonyms	ylxT, yzaA
Essential	no
Product	transcriptional regulator
Function	regulation of gene expression during the transition from growth to stationary phase
Gene expression levels in SubtiExpress: abh
Interactions involving this protein in SubtInteract: Abh
MW, pI	10 kDa, 5.753
Gene length, protein length	276 bp, 92 aa
Immediate neighbours	mreBH, kinC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transition state regulators, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU14480

Phenotypes of a mutant

• inactivation of abh results in sensitivity against beta-lactam antibiotics that can be restored by induction of slrR expression or by inactivation of the genes encoding major autolysins (lytC, lytF) PubMed

Database entries

• BsubCyc: BSU14480

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): AbrB, SpoVT (only N-terminal domain)

Genes controlled by Abh

• slrR PubMed

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • Abh-Abh PubMed
  • AbrB-Abh PubMed

• Localization:

Database entries

• BsubCyc: BSU14480

• Structure: 2FY9 (N-terminal DNA recognition domain)

• UniProt: P39758

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: abh PubMed

• Expression browser: abh PubMed

• Sigma factor: SigX PubMed, SigM PubMed

• Regulation:
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 251 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 866 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Mark Strauch, Baltimore, USA homepage