Upp

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  • Description: uracil phosphoribosyltransferase

Gene name upp
Synonyms ipc-35d
Essential no
Product uracil phosphoribosyltransferase
Function UMP synthesis
Gene expression levels in SubtiExpress: upp
Metabolic function and regulation of this protein in SubtiPathways:
upp
MW, pI 22 kDa, 5.863
Gene length, protein length 627 bp, 209 aa
Immediate neighbours atpI, glyA
Gene sequence (+200bp) Protein sequence
Genetic context
Upp context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Upp expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU36890

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: UPRTase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2EHJ (from Escherichia coli, 52% identity, 73% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 2454 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 6640 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References