SerC

• Description: 3-phosphoserine aminotransferase
  
  

Gene name	serC
Synonyms	yhaF
Essential	no
Product	3-phosphoserine aminotransferase
Function	biosynthesis of serine
Gene expression levels in SubtiExpress: serC
Metabolic function and regulation of this protein in SubtiPathways: serC
MW, pI	39 kDa, 5.522
Gene length, protein length	1077 bp, 359 aa
Immediate neighbours	trpP, hit
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, most abundant proteins

The gene

Basic information

• Locus tag: BSU10020

Database entries

• BsubCyc: BSU10020

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate (according to Swiss-Prot)

• Protein family: SerC subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU10020

• Structure:

• UniProt: P80862

• KEGG entry: [2]

• E.C. number: 2.6.1.52

Expression and regulation

• Operon:

• Expression browser: serC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • belongs to the 100 most abundant proteins PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 2756 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 5019 PubMed

Biological materials

• Mutant:
  • 1A621 ( serC::erm), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Christine Eymann, Annette Dreisbach, Dirk Albrecht, Jörg Bernhardt, Dörte Becher, Sandy Gentner, Le Thi Tam, Knut Büttner, Gerrit Buurman, Christian Scharf, Simone Venz, Uwe Völker, Michael Hecker
A comprehensive proteome map of growing Bacillus subtilis cells.
Proteomics: 2004, 4(10);2849-76
[PubMed:15378759] [WorldCat.org] [DOI] (P p)