MurC

• Description: UDP-N-acetylmuramoyl-L-alanine synthetase
  
  

Gene name	murC
Synonyms	ytxF
Essential	yes PubMed
Product	UDP-N-acetylmuramoyl-L-alanine synthetase
Function	peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: murC
Metabolic function and regulation of this protein in SubtiPathways: murC
MW, pI	48 kDa, 5.307
Gene length, protein length	1296 bp, 432 aa
Immediate neighbours	ytxG, sftA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

The gene

Basic information

• Locus tag: BSU29790

Phenotypes of a mutant

• essential PubMed
• murC is dispensable in wall-less L-forms PubMed

Database entries

• BsubCyc: BSU29790

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine (according to Swiss-Prot)

• Protein family: murCDEF family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (Homogeneous) PubMed

Database entries

• BsubCyc: BSU29790

• Structure:

• UniProt: P40778

• KEGG entry: [3]

• E.C. number: 6.3.2.8

Expression and regulation

• Operon: murC PubMed

• Expression browser: murC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: