rodA
168

SEDS family peptidoglycan glycosyltransferase, part of the elongasome for lateral cell wall synthesis and control of cell diameter

Locus

BSU_38120

Molecular weight

43.12 kDa

Isoelectric point

8.76

Protein length

393 aaSequenceBlast

Gene length

1182 bpSequenceBlast

Function

control of cell shape and elongation

Product

SEDS family peptidoglycan glycosyltransferase

Essential

yes

Synonyms

rodA, ywcF, ipa-42d

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0772 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

3,912,332 → 3,913,513

Phenotypes of a mutant

essential PubMed

CRISPRi knockdown mutant has a terminal phenotype of severe lysis PubMed

The protein

Catalyzed reaction/ biological activity

principal peptidoglycan glycosyltransferase of the elongasome PubMed

[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)]_(n)-diphospho-di-trans,octa-cis-undecaprenol + β-D-GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol --> [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)]_(n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H⁺ (according to UniProt)

Protein family

SEDS proteins (shape, elongation, division, and sporulation) PubMed

SEDS family (with FtsW and SpoVE, according to UniProt)

Structure

6BAR (PDB) (from Thermus thermophilus, 26% identity) PubMed

P39604 (AlphaFold)

Paralogous protein(s)

SpoVE, FtsW

Localization

integral membrane protein PubMed

forms circumferentially moving patches PubMed

localization depends on MreB PubMed