RecJ

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  • Description: single-strand DNA-specific exonuclease

Gene name yrvE
Synonyms recJ
Essential no
Product single-strand DNA-specific exonuclease
Function DNA repair
Gene expression levels in SubtiExpress: yrvE
Interactions involving this protein in SubtInteract: YrvE
Metabolic function and regulation of this protein in SubtiPathways:
yrvE
MW, pI 87 kDa, 5.181
Gene length, protein length 2358 bp, 786 aa
Immediate neighbours apt, yrvD
Sequences Protein DNA DNA_with_flanks
Genetic context
YrvE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YrvE expression.png















Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

stringent response, Efp-dependent proteins

The gene

Basic information

  • Locus tag: BSU27620

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: recJ family (according to Swiss-Prot)
  • Paralogous protein(s): YorK

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:
    • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

  • Mutant:
    • GP895 (recJ::kan), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559] [WorldCat.org] [DOI] (I p)

Original publications