YhdN

• Description: general stress protein, broad specificity aldo-keto reductase that converts MG to acetol
  
  

Gene name	yhdN
Synonyms
Essential	no
Product	aldo/keto reductase, specific for NADP
Function	detoxification of methylglyoxal
Gene expression levels in SubtiExpress: yhdN
Metabolic function and regulation of this protein in SubtiPathways: yhdN
MW, pI	37 kDa, 4.77
Gene length, protein length	993 bp, 331 aa
Immediate neighbours	sigM, plsC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU09530

Phenotypes of a mutant

• increased sensitivity to methylglyoxal PubMed

Database entries

• BsubCyc: BSU09530

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • methylglyoxal --> acetol PubMed

• Protein family: aldo/keto reductase 2 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors: NADPH PubMed

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU09530

• Structure: 1PZ1

• UniProt: P80874

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yhdN-plsC PubMed

• Expression browser: yhdN PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: