AseR

• Description: transcriptional repressor of aseA and aseR
  
  

Gene name	aseR
Synonyms	ydeT
Essential	no
Product	transcriptional repressor (ArsR family)
Function	regulation of As (III) efflux
Gene expression levels in SubtiExpress: aseR
MW, pI	12 kDa, 6.307
Gene length, protein length	333 bp, 111 aa
Immediate neighbours	ydzO, aseA
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

AseR regulon

The AseR regulon:

• aseA, aseR

The gene

Basic information

• Locus tag: BSU05330

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: As(III) acts as molecular inducer PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P96677

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: aseR PubMed

• Sigma factor:

• Regulation:
  • induced by As(III) (AseR) PubMed

• Regulatory mechanism:
  • AseR: transcription repression (autorepression) PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Duncan R Harvie, Claudia Andreini, Gabriele Cavallaro, Wenmao Meng, Bernard A Connolly, Ken-ichi Yoshida, Yasutaro Fujita, Colin R Harwood, David S Radford, Stephen Tottey, Jennifer S Cavet, Nigel J Robinson
Predicting metals sensed by ArsR-SmtB repressors: allosteric interference by a non-effector metal.
Mol Microbiol: 2006, 59(4);1341-56
[PubMed:16430705] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)