BesA

• Description: trilactone hydrolase, catalyses ferri-bacillibactin hydrolysis leading to cytosolic iron release
  
  

Gene name	besA
Synonyms	yuiI
Essential	no
Product	trilactone hydrolase
Function	iron acquisition
Gene expression levels in SubtiExpress: besA
MW, pI	35 kDa, 8.203
Gene length, protein length	942 bp, 314 aa
Immediate neighbours	dhbA, yuiH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acquisition of iron, iron metabolism

This gene is a member of the following regulons

AbrB regulon, Fur regulon, Efp-dependent proteins

The gene

Basic information

• Locus tag: BSU32010

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32102

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: besA PubMed

• Expression browser: besA PubMed

• Sigma factor:

• Regulation:
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: