CoaX

Gene name	coaX
Synonyms	yacB
Essential	no
Product	pantothenate kinase (EC 2.7.1.33)
Function	coenyzmeA synthesis
Gene expression levels in SubtiExpress: coaX
Metabolic function and regulation of this protein in SubtiPathways: Coenzyme A
MW, pI	26 kDa, 8.37
Gene length, protein length	699 bp, 233 aa
Immediate neighbours	ftsH, yacC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

• Locus tag: BSU00700

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)

• Protein family: type III pantothenate kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2H3G (from Bacillus anthracis str. ames, 75% identity, 88% similarity) PubMed

• UniProt: P37564

• KEGG entry: [2]

• E.C. number: 2.7.1.33

Expression and regulation

• Operon: coaX-yacC PubMed

• Expression browser: coaX PubMed

• Sigma factor: SigM PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

Leisl A Brand, Erick Strauss
Characterization of a new pantothenate kinase isoform from Helicobacter pylori.
J Biol Chem: 2005, 280(21);20185-8
[PubMed:15795230] [WorldCat.org] [DOI] (P p)