TcyC

• Description: cystine ABC transporter, ATP-binding protein
  
  

Gene name	tcyC
Synonyms	yckI
Essential	no
Product	cystine ABC transporter, ATP-binding protein
Function	cystine uptake
Interactions involving this protein in SubtInteract: TcyC
MW, pI	27 kDa, 7.188
Gene length, protein length	741 bp, 247 aa
Immediate neighbours	yczE, tcyB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

The gene

Basic information

• Locus tag: BSU03590

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • TcyC-TcyB-TcyA PubMed

• Localization:
  • attached to the membrane via TcyB PubMed

Database entries

• Structure: 2Q0H (in complex with ADP-Mg2+, Geobacillus stearothermophilus, 55% identity)

• UniProt: P39456

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: tcyA-tcyB-tcyC (putative) PubMed

• Expression browser: tcyC PubMed

• Sigma factor:

• Regulation: very weakly expressed under all conditions PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Pierre Burguière, Sandrine Auger, Marie-Françoise Hullo, Antoine Danchin, Isabelle Martin-Verstraete
Three different systems participate in L-cystine uptake in Bacillus subtilis.
J Bacteriol: 2004, 186(15);4875-84
[PubMed:15262924] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

F Rodriguez, G Grandi
An operon encoding a novel ABC-type transport system in Bacillus subtilis.
Microbiology (Reading): 1995, 141 ( Pt 7);1781-4
[PubMed:7551042] [WorldCat.org] [DOI] (P p)