CoaA

• Description: probable pantothenate kinase
  
  

Gene name	coaA
Synonyms	yqjS
Essential	no
Product	probable pantothenate kinase
Function	biosynthesis of coenzyme A
Metabolic function and regulation of this protein in SubtiPathways: Coenzyme A
MW, pI	36 kDa, 5.894
Gene length, protein length	957 bp, 319 aa
Immediate neighbours	yqjT, dsdA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU23760

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

biosynthesis of cofactors

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)

• Protein family: prokaryotic pantothenate kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1SQ5 (from Escherichia coli, 49% identity, 67% similarity) PubMed

• UniProt: P54556

• KEGG entry: [3]

• E.C. number: 2.7.1.33

Expression and regulation

• Operon: yqjP-yqjQ-dsdA-coaA-yqjT (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

W J Song, S Jackowski
Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli.
J Bacteriol: 1992, 174(20);6411-7
[PubMed:1328157] [WorldCat.org] [DOI] (P p)