MmgA

• Description: degradative acetoacetyl-CoA thiolase
  
  

Gene name	mmgA
Synonyms	yqiL
Essential	no
Product	degradative acetoacetyl-CoA thiolase
Function	mother cell metabolism
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	41 kDa, 5.904
Gene length, protein length	1179 bp, 393 aa
Immediate neighbours	mmgB, yqiK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU24170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 acetyl-CoA = CoA + acetoacetyl-CoA (according to Swiss-Prot)

• Protein family: thiolase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P45855

• KEGG entry: [3]

• E.C. number: 2.3.1.9

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: repressed by glucose (CcpA)

• Regulatory mechanism: CcpA: transcription repression

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jason J Reddick, Jayme K Williams
The mmgA gene from Bacillus subtilis encodes a degradative acetoacetyl-CoA thiolase.
Biotechnol Lett: 2008, 30(6);1045-50
[PubMed:18246303] [WorldCat.org] [DOI] (P p)

E M Bryan, B W Beall, C P Moran
A sigma E dependent operon subject to catabolite repression during sporulation in Bacillus subtilis.
J Bacteriol: 1996, 178(16);4778-86
[PubMed:8759838] [WorldCat.org] [DOI] (P p)