pupG
168
purine nucleoside phosphorylase
Locus
BSU_23490
Molecular weight
28.98 kDa
Isoelectric point
4.86
Function
purine salvage and interconversion
Product
purine nucleoside phosphorylase
Essential
no
E.C.
2.4.2.1
Synonyms
pupG, punA, pnp, yqkO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0005 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,446,418 → 2,447,233
The protein
Catalyzed reaction/ biological activity
purine 2'-deoxy-D-ribonucleoside + phosphate --> 2-deoxy-α-D-ribose 1-phosphate + purine nucleobase (according to UniProt)
Protein family
PNP/MTAP phosphorylase family (single member, according to UniProt)
Structure
3LA8 (PDB) (from Streptococcus mutans, 57% identity)
Modification
phosphorylation on Ser-28 PubMed
secreted (according to Swiss-Prot)
Expression and Regulation
Operons
Description
Regulation
induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) PubMed
Regulatory mechanism
Sigma factors
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Biological materials
Mutant
References
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Time of last update: 2025-02-01 16:01:41
Author of last update: Melvin.boenninger