Stusti 2018

Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas

• Riboswitches

• Riboregulation and virulence, targeting by antibiotics

Juan J Quereda, Pascale Cossart
Regulating Bacterial Virulence with RNA.
Annu Rev Microbiol: 2017, 71;263-280
[PubMed:28886688] [WorldCat.org] [DOI] (I p)

Petra Dersch, Muna A Khan, Sabrina Mühlen, Boris Görke
Roles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets.
Front Microbiol: 2017, 8;803
[PubMed:28529506] [WorldCat.org] [DOI] (P e)

Hao Wang, Paul A Mann, Li Xiao, Charles Gill, Andrew M Galgoci, John A Howe, Artjohn Villafania, Christopher M Barbieri, Juliana C Malinverni, Xinwei Sher, Todd Mayhood, Megan D McCurry, Nicholas Murgolo, Amy Flattery, Matthias Mack, Terry Roemer
Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.
Cell Chem Biol: 2017, 24(5);576-588.e6
[PubMed:28434876] [WorldCat.org] [DOI] (I p)

Andreas Matern, Danielle Pedrolli, Stephanie Großhennig, Jörgen Johansson, Matthias Mack
Uptake and Metabolism of Antibiotics Roseoflavin and 8-Demethyl-8-Aminoriboflavin in Riboflavin-Auxotrophic Listeria monocytogenes.
J Bacteriol: 2016, 198(23);3233-3243
[PubMed:27672192] [WorldCat.org] [DOI] (I e)

Aaron M Nuss, Ann Kathrin Heroven, Petra Dersch
RNA Regulators: Formidable Modulators of Yersinia Virulence.
Trends Microbiol: 2017, 25(1);19-34
[PubMed:27651123] [WorldCat.org] [DOI] (I p)

Daniel Dar, Maya Shamir, J R Mellin, Mikael Koutero, Noam Stern-Ginossar, Pascale Cossart, Rotem Sorek
Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria.
Science: 2016, 352(6282);aad9822
[PubMed:27120414] [WorldCat.org] [DOI] (I p)

John A Howe, Hao Wang, Thierry O Fischmann, Carl J Balibar, Li Xiao, Andrew M Galgoci, Juliana C Malinverni, Todd Mayhood, Artjohn Villafania, Ali Nahvi, Nicholas Murgolo, Christopher M Barbieri, Paul A Mann, Donna Carr, Ellen Xia, Paul Zuck, Dan Riley, Ronald E Painter, Scott S Walker, Brad Sherborne, Reynalda de Jesus, Weidong Pan, Michael A Plotkin, Jin Wu, Diane Rindgen, John Cummings, Charles G Garlisi, Rumin Zhang, Payal R Sheth, Charles J Gill, Haifeng Tang, Terry Roemer
Selective small-molecule inhibition of an RNA structural element.
Nature: 2015, 526(7575);672-7
[PubMed:26416753] [WorldCat.org] [DOI] (I p)

• RNA-based second messengers

• Ribozymes

• Protein- or tRNA-controlled RNA switches

• RNA thermometers

Satya Narayan, Mamta H Kombrabail, Sudipta Das, Himanshu Singh, Kandala V R Chary, Basuthkar J Rao, Guruswamy Krishnamoorthy
Site-specific fluorescence dynamics in an RNA 'thermometer' reveals the role of ribosome binding in its temperature-sensitive switch function.
Nucleic Acids Res: 2015, 43(1);493-503
[PubMed:25477380] [WorldCat.org] [DOI] (I p)

• The RNA world and evolution

• RNA modification

• RNA degradation/ processing

• CRISPR/Cas: Science

• CRISPR/Cas: Application