FtsX

• Description: ABC transporter (membrane protein) (FtsE-FtsX), required for CwlO activity (cell elongation) and for proper activation of Spo0A and initiation of sporulation
  
  

Gene name	ftsX
Synonyms
Essential	no
Product	ABC transporter (membrane protein)
Function	control of cell wall synthesis
Gene expression levels in SubtiExpress: ftsX
Interactions involving this protein in SubtInteract: FtsX
MW, pI	32 kDa, 10.016
Gene length, protein length	888 bp, 296 aa
Immediate neighbours	ctpB, ftsE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, cell wall synthesis, phosphorelay, membrane proteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

• Locus tag: BSU35250

Phenotypes of a mutant

• a ftsX mutation is synthetically lethal with a lytE mutation (due to a lack of autolysin activity) PubMed
• shorter, fatter cells, this can be rescued by addition of Mg(2+) PubMed
• reduced growth rate, especially at low Mg(2+) concentrations PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • necessary for the autolysin activity of CwlO PubMed

• Protein family: FtsX subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • FtsE-FtsX PubMed
  • FloT-FtsX PubMed
  • FtsX-CwlO, at the membrane PubMed

• Localization:
  • cell membrane PubMed

Database entries

• Structure:

• UniProt: O34876

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsE-ftsX (according to DBTBS)

• Expression browser: ftsX PubMed

• Sigma factor:

• Regulation:
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: