HelD
- Description: DNA 3'-5' helicase IV, stimulates transcription in an ATP-dependent manner by enhancing transcriptional cycling and elongation
| Gene name | helD |
| Synonyms | yvgS |
| Essential | no |
| Product | DNA 3'-5' helicase IV |
| Function | transcription, DNA repair/ recombination |
| Gene expression levels in SubtiExpress: helD | |
| MW, pI | 89 kDa, 6.083 |
| Gene length, protein length | 2322 bp, 774 aa |
| Immediate neighbours | cysI, yvgT |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
DNA repair/ recombination, transcription
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU33450
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UvrD subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Interactions:
- HelD interacts with the RNA polymerase PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O32215
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- 1A899 ( helD::erm), available at BGSC
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jana Wiedermannová, Petra Sudzinová, Tomaš Kovaľ, Alžbeta Rabatinová, Hana Šanderova, Olga Ramaniuk, Šimon Rittich, Jan Dohnálek, Zhihui Fu, Petr Halada, Peter Lewis, Libor Krásny
Characterization of HelD, an interacting partner of RNA polymerase from Bacillus subtilis.
Nucleic Acids Res: 2014, 42(8);5151-63
[PubMed:24520113]
[WorldCat.org]
[DOI]
(I p)
Olivier Delumeau, François Lecointe, Jan Muntel, Alain Guillot, Eric Guédon, Véronique Monnet, Michael Hecker, Dörte Becher, Patrice Polard, Philippe Noirot
The dynamic protein partnership of RNA polymerase in Bacillus subtilis.
Proteomics: 2011, 11(15);2992-3001
[PubMed:21710567]
[WorldCat.org]
[DOI]
(I p)
B Carrasco, S Fernández, M A Petit, J C Alonso
Genetic recombination in Bacillus subtilis 168: effect of DeltahelD on DNA repair and homologous recombination.
J Bacteriol: 2001, 183(19);5772-7
[PubMed:11544244]
[WorldCat.org]
[DOI]
(P p)
