CotZ

• Description: spore crust protein (insoluble fraction), necessary for the assembly of the spore crust, the outermost layer of the spore coat
  
  

Gene name	cotZ
Synonyms
Essential	no
Product	spore crust protein (insoluble fraction)
Function	spore crust assembly
Gene expression levels in SubtiExpress: cotZ
Interactions involving this protein in SubtInteract: CotZ
MW, pI	16 kDa, 5.102
Gene length, protein length	444 bp, 148 aa
Immediate neighbours	cotO, cotY
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

GerE regulon, SigE regulon, SigK regulon

The gene

Basic information

• Locus tag: BSU11740

Phenotypes of a mutant

• mis-assembly of the spore crust PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • CotY-CotZ PubMed
  • CotZ is required for the proper spore crust localization of CotY PubMed

• Localization:
  • outermost layer of the spore coat (crust), localization depends on CotE PubMed
  • more abundant at the mother cell-proximal pole of the forespore PubMed

Database entries

• Structure:

• UniProt: Q08312

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cotY-cotZ PubMed

• Expression browser: cotZ PubMed

• Sigma factor: SigK PubMed, SigE PubMed

• Regulation:
  • expressed late during sporulation in the mother cell (SigK) PubMed

• Regulatory mechanism:
  • GerE: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: