YtdI

• Description: inorganic polyphosphate/ATP-NAD kinase
  
  

Gene name	ytdI
Synonyms	ppnKB
Essential	no
Product	inorganic polyphosphate/ATP-NAD kinase
Function	generation of NADP from NAD
Gene expression levels in SubtiExpress: ytdI
MW, pI	30 kDa, 6.49
Gene length, protein length	801 bp, 267 aa
Immediate neighbours	sppA, ytcJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU29540

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + NAD⁺ = ADP + NADP⁺ (according to Swiss-Prot)

• Protein family: NAD kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1YT5 (from Thermotoga maritima) PubMed

• UniProt: O34934

• KEGG entry: [2]

• E.C. number: 2.7.1.23

Expression and regulation

• Operon: ytdI PubMed

• Expression browser: ytdI PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947

Vaheh Oganesyan, Candice Huang, Paul D Adams, Jaru Jancarik, Hisao A Yokota, Rosalind Kim, Sung-Hou Kim
Structure of a NAD kinase from Thermotoga maritima at 2.3 A resolution.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2005, 61(Pt 7);640-6
[PubMed:16511117] [WorldCat.org] [DOI] (I p)