AdhA

• Description: thiol-dependent aldehyde dehydrogenase, repair of damaged thiol-containing proteins
  
  

Gene name	adhA
Synonyms
Essential	no
Product	thiol-dependent aldehyde dehydrogenase, reduction of aldehydes
Function	response to toxic formaldehyde
MW, pI	37 kDa, 5.367
Gene length, protein length	1047 bp, 349 aa
Immediate neighbours	adhR, yraA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

AdhR regulon

The gene

Basic information

• Locus tag: BSU27010

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: C0SPA5

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: adhA-yraA PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde (AdhR) PubMed

• Regulatory mechanism:
  • AdhR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)