bpsA

bpsA
168

type III polyketide synthase

Locus
BSU_22050
Molecular weight
40.55 kDa
Isoelectric point
7.96
Protein length
365 aaSequenceBlast
Gene length
1098 bpSequenceBlast
Function
polyketide synthesis
Product
type III polyketide synthase
Essential
no
E.C.
2.3.1.74
Synonyms
bpsA, bcsA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3424 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,316,956  2,318,053
The protein
Catalyzed reaction/ biological activity
synthesis of triketide pyrones from long-chain fatty acyl CoA thioesters as starter substrates and malonyl-CoA as an extender substrate PubMed
4-coumaroyl-CoA + 2 H+ + 3 malonyl-CoA --> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA (according to UniProt)
Protein family
thiolase-like superfamily (according to UniProt)
Structure
4JAO (PDB) (from Mycobacterium tuberculosis, 34% identity) PubMed
P54157 (AlphaFold)
Expression and Regulation
Operons
Genes
bpsA-bpsB
Description
PubMed
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bpsA→bpsB

2025-04-10 16:49:00

ghost

89

8889bdbb47d5cd3070f477acb378e4900fe1a36a

9E921FCD7E68BD3C0070A5633C1B3121483061F8

Biological materials
Mutant
MGNA-A875 (bcsA::erm), available at the NBRP B. subtilis, Japan
BKE22050 (''bpsA::erm'', available in the BGSC and in Jörg Stülke's lab) PubMed
GP1820 (''bpsA::erm'', available in Jörg Stülke's lab)
BKE22050 (bpsA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCGATCACCTCTTTGCA,  downstream forward: _UP4_AGCTGGGAAAAGGGGGCCTG
BKK22050 (bpsA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCGATCACCTCTTTGCA,  downstream forward: _UP4_AGCTGGGAAAAGGGGGCCTG
References
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7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C

Page visits: 3017

Time of last update: 2025-04-14 17:40:10

Author of last update: Melvin.boenninger