PolC
- Description: DNA polymerase III (alpha subunit), part of the replisome
Gene name | polC |
Synonyms | mutI, dnaF, dnaP |
Essential | yes PubMed |
Product | DNA polymerase III (alpha subunit) |
Function | DNA replication |
Gene expression levels in SubtiExpress: polC | |
Interactions involving this protein in SubtInteract: PolC | |
MW, pI | 162 kDa, 5.135 |
Gene length, protein length | 4311 bp, 1437 aa |
Immediate neighbours | proS, ylxS |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16580
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
- required for bacteriophage SPP1 replication PubMed
- Protein family: PolC subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- forms foci PubMed
- cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P13267
- KEGG entry: [2]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Meindert H Lamers, Mike O'Donnell
A consensus view of DNA binding by the C family of replicative DNA polymerases.
Proc Natl Acad Sci U S A: 2008, 105(52);20565-6
[PubMed:19106294]
[WorldCat.org]
[DOI]
(I p)
Original publications