PadR

• Description: repressor of yveF-yveG-padC, induction occurs by binding of phenolic acids,stress response
  
  

Gene name	padR
Synonyms	yfiO
Essential	no
Product	transcriptional repressor
Function	regulation of the phenolic acid stress response
Gene expression levels in SubtiExpress: padR
MW, pI	21 kDa, 7.231
Gene length, protein length	546 bp, 182 aa
Immediate neighbours	yfiN, lipB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

The PadR regulon:

• yveF-yveG-padC

The gene

Basic information

• Locus tag: BSU08340

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: phenolic acid acts as molecular inducer and releases PadR from the yveF-yveG-padC promoter PubMed

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P94443

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: padR (according to DBTBS)

• Expression browser: padR PubMed

• Sigma factor:

• Regulation: weak constitutive expression

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Thi Kim Chi Nguyen, Ngoc Phuong Tran, Jean-François Cavin
Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168.
J Bacteriol: 2011, 193(16);4180-91
[PubMed:21685295] [WorldCat.org] [DOI] (I p)

Ngoc Phuong Tran, Jerôme Gury, Véronique Dartois, Thi Kim Chi Nguyen, Hélène Seraut, Lise Barthelmebs, Patrick Gervais, Jean-François Cavin
Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis.
J Bacteriol: 2008, 190(9);3213-24
[PubMed:18326577] [WorldCat.org] [DOI] (I p)