Rok
- Description: repressor of comK, nucleoid associated protein that serves to help repress expression of A+T-rich genes, many of which appear to have been acquired by horizontal gene transfer
Gene name | rok |
Synonyms | ykuW |
Essential | no |
Product | transcriptional repressor |
Function | regulation of genetic competence |
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
MW, pI | 21 kDa, 9.701 |
Gene length, protein length | 573 bp, 191 aa |
Immediate neighbours | ykuV, yknT |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
genetic competence, transcription factors and their control
This gene is a member of the following regulons
AbrB regulon, Rok regulon, SinR regulon, Spo0A regulon
The Rok regulon
The gene
Basic information
- Locus tag: BSU14240
Phenotypes of a mutant
higher excision rate of the conjugative transposon ICEBs1 PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binds to extended regions of the B. subtilis genome that are characterized by a high A+T content and are known or believed to have been acquired by horizontal gene transfer PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34857
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: rok PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications